In vitro, the creos xenoprotect (Nobel Biocare / Remaix, Matricel) showed significantly greater tensile strength in terms of both force at break (N) and stress at break (N/mm²) and in terms of suture retention when compared to a bi-layer non-cross-linked collagen membrane (Bio-Gide, Geistlich).
An accompanying animal study confirmed slower biodegradation of creos xenoprotect. Degradation was similar between the two membranes during the first nine weeks, but a marked difference at 20 weeks showed only a slight decrease in thickness of the creos xenoprotect membrane compared to 51% loss of thickness of the comparison membrane.
Histomorphometric analyses at 20 weeks showed higher vascularization of the creos xenoprotect membrane with approximately two-fold increase in the number of blood vessels at week 20.
1 Bozkurt A, Apel C, Sellhaus B, van Neerven S, Wessing B, Hilgers RD, Pallua N. COIR 2013 [epub 28 October] DOI: 10.1111/clr.12284.